Dataset Information
Transcription profiling of human melanoma cell lines treated with 2-deoxy-5-azacytidine
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Edward Fox
PROVIDER: E-GEOD-1793 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies.
Carcinogenesis 20050615 11
The incidence of melanoma is increasing rapidly, with advanced lesions generally failing to respond to conventional chemotherapy. Here, we utilized DNA microarray-based gene expression profiling techniques to identify molecular determinants of melanoma progression within a unique panel of isogenic human melanoma cell lines. When a poorly tumorigenic cell line, derived from an early melanoma, was compared with two increasingly aggressive derivative cell lines, the expression of 66 genes was signi ...[more]
