Japanese human fibroblasts: Healthy vs. Pachydermoperiostosis (PDP)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jun-ichi Sakabe
PROVIDER: E-GEOD-17947 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Involvement of Wnt signaling in dermal fibroblasts.
Kabashima Kenji K Sakabe Jun-Ichi J Yoshiki Ryutaro R Tabata Yasuhiko Y Kohno Kimitoshi K Tokura Yoshiki Y
The American journal of pathology 20091230 2
Pachydermoperiostosis (PDP) is a rare disease characterized by unique phenotypes of the skin and bone, such as thick skin, implying that it may be caused by dysregulation of mesenchymal cells. The aim of this study is to examine the roles of dermal fibroblasts in the pathogenesis of pachydermia in association with Wnt signaling. The numbers of cultured fibroblasts were compared between healthy donors and PDP patients, and mRNA expression profiles in cultured dermal fibroblasts were examined by D ...[more]
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