Expression data of FB2 vs. FB2khd4Delta

ABSTRACT: RNA-binding proteins constitute key factors of the posttranscriptional machinery. These regulatory proteins recognise specific elements within target transcripts to promote e.g. maturation, translation or stability of mRNAs. In Ustilago maydis, evidence is accumulating that posttranscriptional processes are important to determine pathogenicity. Deletion of khd4, encoding a predicted RNA-binding protein with five K homology (KH) domains, causes aberrant cell morphology and reduced virulence. Here, we demonstrate that Khd4 recognises the sequence AUACCC in vivo via its tandem KH domains 3 and 4. This sequence functions most likely as regulatory RNA element in U. maydis, since it accumulates in 3’ untranslated regions. Consistently, an independent transcriptional profiling approach revealed

ORGANISM(S): Ustilago maydis

SUBMITTER: Michael Feldbrügge 

PROVIDER: E-GEOD-17956 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress