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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from regulatory T cells with Stat3 ablation

ABSTRACT: We used microarrays to detail the global programme of gene expression dependent upon Stat3 in regulatory T cells Regulatory T cells isolated from Foxp3 Stat3 or Foxp3 Stat3 were isolated using FACS based sorting followed by RNA extraction, amplification, labeling and hybridization on Affymatrix Microarray

ORGANISM(S): Mus musculus

SUBMITTER: Ashutosh Chaudhry

PROVIDER: E-GEOD-17962 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.

Chaudhry Ashutosh A Rudra Dipayan D Treuting Piper P Samstein Robert M RM Liang Yuqiong Y Kas Arnold A Rudensky Alexander Y AY

Science (New York, N.Y.) 20091001 5955

Distinct classes of protective immunity are guided by activation of STAT transcription factor family members in response to environmental cues. CD4+ regulatory T cells (T(regs)) suppress excessive immune responses, and their deficiency results in a lethal, multi-organ autoimmune syndrome characterized by T helper 1 (TH1) and T helper 2 (TH2) CD4+ T cell-dominated lesions. Here we show that pathogenic TH17 responses in mice are also restrained by T(regs). This suppression was lost upon T(reg)-spe ...[more]

PMID: 19797626

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Genome-wide binding of STAT3 and STAT5 under Th17 conditions (ChIP-Seq)

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Roles of STAT3 and STAT5 in regulation of gene expression under Th17 differentiation

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Microarray analysis of WT, SKO, PKO and DKO liver samples

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