MicroRNAs of Bombyx mori identified by Solexa sequencing

ABSTRACT: Background: MicroRNA (miRNA) and other small regulatory RNAs contribute to the modulation of a large number of cellular processes. We sequenced three total RNA libraries prepared from the whole body, and the anterior and posterior silk glands of Bombyx mori, with a view to expanding the repertoire of silkworm miRNAs and exploring transcriptional differences in miRNAs between segments of the silk gland. Results: With the aid of large-scale Solexa sequencing technology, we validated 244 unique miRNA genes, including 191 novel and 53 previously reported genes, corresponding to 309 loci in the silkworm genome. Interestingly, 24 unique miRNAs were widely conserved from invertebrates to vertebrates; 12 unique ones were limited to invertebrates and 33 were confined to insects; whereas the majorit

ORGANISM(S): Bombyx mori

SUBMITTER: Qingyou Xia 

PROVIDER: E-GEOD-17965 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress