Genomic Phenotype Of Non-Cultured IPF Fibroblasts

ABSTRACT: The activated fibroblast is the central effector cell for the progressive fibrotic process that characterizes idiopathic pulmonary fibrosis (IPF). An understanding of the genomic phenotype of this cell in isolation is essential to the understanding of disease pathogenesis and is integral to strategizing therapeutic trials. Employing a unique technique that minimizes cellular phenotypic alterations, we characterized the genomic phenotype of non-cultured pulmonary fibroblasts from the lungs of patients with advanced IPF. This approach revealed several novel genes and pathways previously unreported in IPF fibroblasts. Specifically, we demonstrate altered expression in proteasomal constituents, ubiquitination mediators, the Wnt pathway and several cell cycle regulators suggestive of loss of n

ORGANISM(S): Homo sapiens

SUBMITTER: Margaret Emblom-Callahan 

PROVIDER: E-GEOD-17978 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress