Expression profiling after ICAP1 or constitutive active NOTCH1 over expression in human umbilical vein endothelial cells

ABSTRACT: ICAP1 (also known as ITG1BP1) is a protein interaction partner of beta1-integrins and the cerebral cavernous malformation protein 1 (CCM1, also known as KRIT1). In mice Icap1 plays an important role for bone development. The function of ICAP1 in endothelial cells is poorly understood. However, the interactions with beta1-integrins and CCM1 suggest that ICAP1 should play an important role also in endothelial cells. We obtained data that ICAP1 might activate the Delta-Notch signaling cascade, a critical regulator of endothelial proliferation, migration and sprouting angiogenesis. This genome-wide expression analysis is aimed to unravelling novel mechanisms or signaling pathways how ICAP1 functions in endothelial cells. Secondly, this study aimed at defining novel target genes of Notch signal

ORGANISM(S): Homo sapiens

SUBMITTER: Andreas Fischer 

PROVIDER: E-GEOD-18035 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress