Propionibacterium acnes as a frequent inflammatory agent involved in prostate cancer

ABSTRACT: Prostate cancer is the second leading cause of male cancer deaths in the United States and Europe. Current evidence implicates an inflammatory mechanism as a cause of prostate carcinogenesis. Here we show that the bacterium Propionibacterium acnes (P. acnes) is prevalent in prostate glandular tissues: 70% of benign hyperplasia and 81% of cancer tissue samples tested positive for the bacterium. Live P. acnes bacteria were isolated from cancerous prostates and co-cultured with epithelial prostate cells to confirm they were cell invasive. Transcriptome and ELISA studies revealed that P. acnes induced a strong inflammatory response in prostate cells, resulting in the secretion of cytokines and chemokines such as interleukin (IL)-6 and IL-8. In addition, P. acnes triggered the COX prostaglandin

ORGANISM(S): Homo sapiens

SUBMITTER: Hans-Joachim Mollenkopf 

PROVIDER: E-GEOD-18109 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress