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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Human iPS cells and fibroblasts

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE18226: Expression data from human iPS cells and fibroblasts GSE18227: DNA methylation data from human iPS cells and fibroblasts Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: In-Hyun Park

PROVIDER: E-GEOD-18111 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.

Doi Akiko A Park In-Hyun IH Wen Bo B Murakami Peter P Aryee Martin J MJ Irizarry Rafael R Herb Brian B Ladd-Acosta Christine C Rho Junsung J Loewer Sabine S Miller Justine J Schlaeger Thorsten T Daley George Q GQ Feinberg Andrew P AP

Nature genetics 20091101 12

Induced pluripotent stem (iPS) cells are derived by epigenetic reprogramming, but their DNA methylation patterns have not yet been analyzed on a genome-wide scale. Here, we find substantial hypermethylation and hypomethylation of cytosine-phosphate-guanine (CpG) island shores in nine human iPS cell lines as compared to their parental fibroblasts. The differentially methylated regions (DMRs) in the reprogrammed cells (denoted R-DMRs) were significantly enriched in tissue-specific (T-DMRs; 2.6-fol ...[more]

PMID: 19881528

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