Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Michael Krause
PROVIDER: E-GEOD-18130 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Love Dona C DC Ghosh Salil S Mondoux Michelle A MA Fukushige Tetsunari T Wang Peng P Wilson Mark A MA Iser Wendy B WB Wolkow Catherine A CA Krause Michael W MW Hanover John A JA
Proceedings of the National Academy of Sciences of the United States of America 20100405 16
Nutrient-driven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene expression in metazoans. The global effects of GlcNAcylation on transcription can be addressed directly in C. elegans because knockouts of the O-GlcNAc cycling enzymes are viable and fertile. Using anti-O-GlcNAc ChIP-on-chip whole-genome tiling arrays on wild-type and mutant strains, we detected over 800 promoters where O-GlcNAc cycling occurs, including microRNA loci and multigene o ...[more]