Array-based gene expression in neuroblastic tumors

ABSTRACT: Title: Array-based gene expression, CGH and tissue data define a 12q24 gain in neuroblastic tumors with prognostic implication. Background: Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a few clinically useful prognostic markers have been found. Here, we present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for neuroblastoma. Methods: A single-gene resolution aCGH profiling was integrated with microarray-based gene expression profiling data to distinguish genetic copy number alterations that were strongly associated with transcriptional changes i

ORGANISM(S): Homo sapiens

SUBMITTER: Maija Wolf 

PROVIDER: E-GEOD-18139 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress