Transcriptomic alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi

ABSTRACT: We examined the extent to which different Trypanosoma cruzi strains induce transcriptomic changes in cultured L6E9 myoblasts 72 hours or 48 hours after infection with four strains of the parasite [Brazil (TCI); Y, CL and Tulahuen (TC II) strains]. Expression of 6,289 distinct fully annotated unigenes was quantified with 27k rat oligonucleotide arrays in each of the four replicas of all control and infected RNA samples. Considering changes >1.5-fold and p-val<0.05, the Tulahuen strain was the most disruptive to host transcriptome, with (17% significantly altered genes), while in Y strain altered only 6% of the genes were altered. The significantly altered genes in the infected cells were largely different among the four strains, with only 21 genes changed in the same direction being similar

ORGANISM(S): Rattus norvegicus

SUBMITTER: Dumitru Iacobas 

PROVIDER: E-GEOD-18175 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress