Transcription profiling of mouse lateral, medial and intermediolateral column motoneurons following spinal cord transection

ABSTRACT: To determine spinal cord injury (SCI) induced changes in gene expression, laser capture microscopy (LCM) and Affymetrix microarrays were used to profiles three distinct populations of motor neurons (MNs) in five sets of littermates. In each set, one littermate received a lamenectomy (sham operated), and the other received a complete spinal cord transection. Each MN population was caudal to the transection and not axotomized. Thus, MNs in transected animals were responding to two major insults: deafferentation and changing microenvironments due to spreading immune and inflammatory responses. A total of 30 expression profiles from sham operated control animals have been uploaded to GEO database with accession number GSE2595. The current series contains 32 motoneuron expression profiles from

ORGANISM(S): Mus musculus

SUBMITTER: Dapeng Cui 

PROVIDER: E-GEOD-18179 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress