Expression profiling of asense mutant VNC cells in Drosophila embryos

ABSTRACT: The expression profile of asense mutant neuroblasts and GMCs were compared to wildtype in order to investigate the function of Asense in neural development. Abstract of paper: Neural stem cells must strike a balance between self-renewal and multipotency, and differentiation. Identification of the transcriptional networks regulating stem cell division is an essential step in understanding how this balance is achieved. We have shown that the homeodomain transcription factor, Prospero, acts to repress self-renewal and promote differentiation. Amongst its targets are three neural stem cell transcription factors, Asense, Deadpan and Snail, of which Asense and Deadpan are repressed by Prospero. Here we identify the targets of these three factors throughout the genome. We find a large overlap in

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Tony Southall 

PROVIDER: E-GEOD-18214 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress