Transcription profiling of S. cerevisiae response to high furfural is based on NADPH-dependent reduction by at least two oxireductases

ABSTRACT: Resistance of Saccharomyces cerevisiae to high furfural concentration is based on NADPH-dependent reduction by at least two oxireductases. Biofuels derived from lignocellulosic biomass hold promises for a sustainable fuel economy, but several problems hamper their economical feasibility. One important problem is the presence of toxic compounds in processed lignocellulosic hydrolysates with furfural as a key toxin. While Saccharomyces cerevisiae has some intrinsic ability to reduce furfural to the less toxic furfuryl alcohol, higher resistance is necessary for process conditions. By comparing an evolved, furfural resistant strain and its parent in micro-aerobic, glucose-limited chemostats at increasing furfural challenge, we elucidate key mechanism and the molecular basis of both natural an

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Dominik Heer 

PROVIDER: E-GEOD-18314 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress