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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human vastus lateralis muscle from exercised and non-exercised subjects

ABSTRACT: Four healthy human volunteers underwent an acute bout of resistance exercise with the right leg at 2 pm. Biopsies were removed from the Vastus Lateralis muscle 6 h (8 pm) and 18 h (8 am) after exericise

ORGANISM(S): Homo sapiens

SUBMITTER: Alexander Zambon

PROVIDER: E-GEOD-1832 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Time- and exercise-dependent gene regulation in human skeletal muscle.

Zambon Alexander C AC McDearmon Erin L EL Salomonis Nathan N Vranizan Karen M KM Johansen Kirsten L KL Adey Deborah D Takahashi Joseph S JS Schambelan Morris M Conklin Bruce R BR

Genome biology 20030925 10

<h4>Background</h4>Skeletal muscle remodeling is a critical component of an organism's response to environmental changes. Exercise causes structural changes in muscle and can induce phase shifts in circadian rhythms, fluctuations in physiology and behavior with a period of around 24 hours that are maintained by a core clock mechanism. Both exercise-induced remodeling and circadian rhythms rely on the transcriptional regulation of key genes.<h4>Results</h4>We used DNA microarrays to determine the ...[more]

PMID: 14519196

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Time and Exercise effects on Human Skeletal Muscle

Project description:Four healthy human volunteers underwent an acute bout of resistance exercise with the right leg at 2 pm. Biopsies were removed from the Vastus Lateralis muscle 6 h (8 pm) and 18 h (8 am) after exericise Keywords = Human skeletal muscle Keywords = resistance exerise Keywords = diurnal Keywords = circadian Keywords: time-course

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Vastus lateralis muscle aging

Project description:Development of a method to identify age-regulated expression trends in skeletql muscles and study the underlying molecular processes of the age_associated progressive changes in skeletal muscles. See abstract from associated manuscript belowÂ : Aging is characterized by progressive tissue degeneration and it is associated with genome-wide changes of mRNA expression profiles. Therefore, it is expected that age-regulated changes in expression profiles could describe the process of aging. We have developed a robust and unbiased methodology to identify age-regulated expression trends in cross-sectional data sets from healthy donors. Our analysis in four different tissues reveals that in brain cortex and Vastus lateralis muscles, two major age-associated expression inclinations were found, one during midlife and one in elderly. In kidney medulla and cortex, however, transcriptional changes were found only in elderly. In concurrence with increased degeneration in aged tissue, the elderly-associated expression changes are predominantly downwards. Our results suggest that a non-linear trend describes the aging process, and can be the result of inclinations of gene expression at two distinct age-positions affecting different molecular and cellular processes. RNA was extracted from vastus lateralis muscles. cDNA synthesis and labeling were preformed with the Illumina cDNA labeling kit.

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2009-03-13 | E-GEOD-10828 | biostudies-arrayexpress

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