Gene expression of Streptococcus mutans pknB mutant versus wild type strain

ABSTRACT: Bacteria can detect, transmit and react to signals from the outside world by using two-component systems an serine-threonine kinases and phosphatases. Streptococcus mutans contains one serine-threonine kinase, encoded by pknB. A gene encoding a serine-threonine phosphatase, pppL, is located downstream of pknB. In this study, the phenotypes of single mutants in pknB and pppL and a pknBpppL double mutant were characterized. All mutants exhibited a reduction in genetic transformability and biofilm formation, showed abnormal cell shapes, grew slower than the wild type strain in several complex media and had lost acid tolerance. The mutants had reduced cariogenic capacity, but no defects in colonization in a rat caries model. Whole genome transcriptome analysis revealed that pknB mutant showed

ORGANISM(S): Streptococcus mutans UA159

SUBMITTER: Danusia Banu 

PROVIDER: E-GEOD-18355 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress