Transcriptional profiling of response to acute caloric restriction in liver and fat of pigs differing in feed efficiency

ABSTRACT: Residual feed intake (RFI) is a measure of feed efficiency, where low RFI denotes high feed efficiency. Caloric restriction (CR) is associated with feed efficiency in livestock species and to human health benefits such as longevity and cancer prevention. We have developed pig lines that differ in RFI and are interested to identify the genes and pathways that underlie feed efficiency. Prepubertal Yorkshire gilts with low RFI (n=10) or high RFI (n=10) were fed ad libitum or at 80% of maintenance for eight days. We measured serum metabolites and generated transcriptional profiles of liver and subcutaneous adipose tissue. 6,114 genes in fat and 305 genes in liver were differentially expressed (DE) in response to CR and 311 in fat and 147 in liver were DE due to RFI differences. Pathway analys

ORGANISM(S): Sus scrofa

SUBMITTER: Sender Lkhagvadorj 

PROVIDER: E-GEOD-18359 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress