Murine CD4+ T cells from DEREG mice expressing GFP under the control of the FoxP3 promotor

ABSTRACT: Naturally occurring CD25+CD4+ regulatory T cells (T reg cells) are currently intensively characterized because of their major importance in modulating host responses to tumors and infections, in preventing transplant rejection, and in inhibiting the development of autoimmunity and allergy. Originally, CD4+ T reg cells were identified exclusively by the constitutive expression of CD25, and many in vivo experiments have been performed using depleting antibodies directed against CD25. However, both the existence of CD25– T reg cells, especially within peripheral tissues, as well as the expression of CD25 on activated conventional T cells, which precludes discrimination between T reg cells and activated conventional T cells, limits the interpretation of data obtained by the use of anti-CD25 de

ORGANISM(S): Mus musculus

SUBMITTER: Robert Geffers 

PROVIDER: E-GEOD-18387 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress