Copy number profiling of PE ovarian cancer lines
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Charlotte Ng
PROVIDER: E-GEOD-18461 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.
Cooke S L SL Ng C K Y CK Melnyk N N Garcia M J MJ Hardcastle T T Temple J J Langdon S S Huntsman D D Brenton J D JD
Oncogene 20100628 35
Resistance to chemotherapy in ovarian cancer is poorly understood. Evolutionary models of cancer predict that, following treatment, resistance emerges either because of outgrowth of an intrinsically resistant sub-clone or evolves in residual disease under the selective pressure of treatment. To investigate genetic evolution in high-grade serous (HGS) ovarian cancers, we first analysed cell line series derived from three cases of HGS carcinoma before and after platinum resistance had developed (P ...[more]
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