Fatigue-related HIV disease gene-networks identified in CD14+ cells isolated from HIV-infected patients

ABSTRACT: HIV-related fatigue is multi-causal in origin and potentially related to mitochondrial dysfunction caused by toxicity from nucleoside reverse transcriptase inhibitor (NRTI) antiretroviral therapy. CD14+ cells are undifferentiated macrophages, vulnerable to HIV infection, and easily accessible for gene expression experiments in a purified cell population. We utilized a novel mitochondrially-specific gene expression microarray to assess mitochondrial and nuclear genes in CD14+ cells of low- and high-fatigued, NRTI-treated HIV/AIDS patients (n=5 each). Novel Bayesian and liquid association network methods identified 33 genes predictive of low versus high fatigue and 32 genes predictive of healthy versus HIV infection. Sulfotransferase 2B1 (SULT2B1) is relevant to both the cholesterol and test

ORGANISM(S): Homo sapiens

SUBMITTER: Marinos Dalakas 

PROVIDER: E-GEOD-18468 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress