A novel metabolic monitoring system identified nutrition-mediated microbial interactions

ABSTRACT: "Omics" technologies have been developed to understand the whole complex microbial systems; however, most omics studies reported so far were utilized to analyze the living matters of “single-species”. To understand the cell-cell interaction in the gut microbial complex, we selected to examine the interaction of Escherichia coli O157:H7 (O157) and Bifidobacterium longum (BL), known as a pathogenic and a commensal bacteria, as a first step for understanding the whole gut microbial complex. We have developed a novel time-lapse 2D-NMR metabolic profiling system in order to measure the extracellular metabolites, which are considered a key factor to understand the bacterial crosstalk. Furthermore, in combination with transcriptome and proteome analysis, we found that the relationship b

ORGANISM(S): Escherichia coli

SUBMITTER: Shinji Fukuda 

PROVIDER: E-GEOD-18474 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress