Dataset Information
CDK inhibitors PHA-848125 and PHA-690509 profiling on A2780
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Roberta Bosotti
PROVIDER: E-GEOD-18486 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Discovery of drug mode of action and drug repositioning from transcriptional responses.
Proceedings of the National Academy of Sciences of the United States of America 20100802 33
A bottleneck in drug discovery is the identification of the molecular targets of a compound (mode of action, MoA) and of its off-target effects. Previous approaches to elucidate drug MoA include analysis of chemical structures, transcriptional responses following treatment, and text mining. Methods based on transcriptional responses require the least amount of information and can be quickly applied to new compounds. Available methods are inefficient and are not able to support network pharmacolo ...[more]
