MiR-193b represses cell proliferation and regulates cyclin D1 in melanoma: benign nevi and metastatic melanoma

ABSTRACT: Cutaneous melanoma is an increasingly common form of skin cancer. The molecular mechanisms regulating melanoma progression are not completely understood. We speculated that specific miRNAs may be involved in melanoma development. We compared the miRNA expression profiles of benign nevi and metastatic melanomas. Unsupervised hierarchical clustering demonstrated a distinct miRNA expression pattern in metastatic melanomas compared to nevi. We identified miRNAs that were differentially expressed in melanoma. Notably, miR-193b was significantly down-regulated in the melanoma tissue examined. Using functional studies we demonstrated that over-expression of miR-193b significantly reduced melanoma cell proliferation, and arrested cell at G1 phase. Further gene expression analysis revealed that miR

ORGANISM(S): Homo sapiens

SUBMITTER: Jiamin Chen 

PROVIDER: E-GEOD-18509 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress