Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Low dose human chorionic gonadotropin hCG

ABSTRACT: Influence of ovarian stimulation with 200 IU of hCG, (administered in the late follicular phase among ICSI patients undergoing a GnRH-antagonist protocol), on the endometrium on the day of oocyte pick-up. The purpose of the present study is to assess the influence of the administration of low dose hCG on the endometrium. In addition, by analysing the correlation of the morphological pattern and gene expression profile of human endometrium on the day of oocyte retrieval in patients of both treatment groups, we want to study the implantation potential. Keywords: gene expression analysis In total 10 samples from patients without pregnancy following embryo transfer were analyzed for gene expression analysis with microarrays, 5 patients from group A (rFSH group) and 5 patients from group B (hCG group) were compared

ORGANISM(S): Homo sapiens

SUBMITTER: Leentje Van Lommel 

PROVIDER: E-GEOD-18557 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profile in the endometrium on the day of oocyte retrieval after ovarian stimulation with low-dose hCG in the follicular phase.

Blockeel Christophe C   Van Vaerenbergh Inge I   Fatemi Human Mousavi HM   Van Lommel Leentje L   Devroey Paul P   Bourgain Claire C  

Molecular human reproduction 20100812 1

The past decade has seen growing interest in ovarian stimulation protocols with GnRH antagonists in an effort to reduce the incidence of potential complications, such as cyst formation and ovarian hyperstimulation syndrome, and thus improve the clinical experience for patients. Current assisted reproductive technique programmes also increasingly utilize milder protocols for ovarian stimulation. In a recently published randomized controlled trial, we showed that low-dose hCG can be utilized clini  ...[more]

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