Time-course gene expression data from deletion strains of Penicillium chrysogenum

ABSTRACT: The recent discovery of a velvet complex containing several regulators of secondary metabolism in the model fungus Aspergillus nidulans raises the question whether similar type complexes direct fungal development in genera other than Aspergillus. Penicillium chrysogenum is the industrial producer of the antibiotic penicillin, whose biosynthetic regulation is barely understood. Here we provide a functional analysis of two major homologues of the velvet complex in P. chrysogenum, that we have named PcvelA and PclaeA. Data from array analysis using a ?PcvelA deletion strain indicate a significant role of PcvelA on the expression of biosynthesis and developmental genes, including PclaeA. Northern hybridization and HPLC quantifications of penicillin titres clearly show that both PcvelA and Pcla

ORGANISM(S): Penicillium chrysogenum

SUBMITTER: Jens Kamerewerd 

PROVIDER: E-GEOD-18585 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress