Transcription profiling of human induced pluripotent stem cells signature and memory retention

ABSTRACT: Transient expression of two factors, or from Oct4 alone, resulted in efficient generation of human iPSCs. The reprogramming strategy described revealed a potential transcriptional signature for human iPSCs yet retaining the gene expression of donor cells in human reprogrammed cells free of viral and transgene interference. Genetic reprogramming of somatic cells to a pluripotent state (induced pluripotent stem cells or iPSCs) by over-expression of specific genes has been accomplished using mouse and human cells. However, it is still unclear how similar human iPSCs are to human Embryonic Stem Cells (hESCs). Here, we describe the transcriptional profile of human iPSCs generated without viral vectors or genomic insertions, revealing that these cells are in general similar to hESCs but with sig

ORGANISM(S): Homo sapiens

SUBMITTER: Alysson Muotri 

PROVIDER: E-GEOD-18618 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress