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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human hearts exhibiting ischemic and nonischemic cardiomyopathy

ABSTRACT: Pre-LVAD and explanted ischemic and nonischemic cardiomyopathy and nonfailing hearts all normalized with RMA

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Michelle Kittleson

PROVIDER: E-GEOD-1869 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failure.

Kittleson Michelle M MM Minhas Khalid M KM Irizarry Rafael A RA Ye Shui Q SQ Edness Gina G Breton Elayne E Conte John V JV Tomaselli Gordon G Garcia Joe G N JG Hare Joshua M JM

Physiological genomics 20050315 3

Cardiomyopathy can be initiated by many factors, but the pathways from unique inciting mechanisms to the common end point of ventricular dilation and reduced cardiac output are unclear. We previously described a microarray-based prediction algorithm differentiating nonischemic (NICM) from ischemic cardiomyopathy (ICM) using nearest shrunken centroids. Accordingly, we tested the hypothesis that NICM and ICM would have both shared and distinct differentially expressed genes relative to normal hear ...[more]

PMID: 15769906

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Ischemic and Nonischemic CM and NF Hearts

Project description:Pre-LVAD and explanted ischemic and nonischemic cardiomyopathy and nonfailing hearts all normalized with RMA Keywords: other

2004-10-26 | GSE1869 | GEO

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Project description:Our understanding of heart failure (HF) has been provided by indirect surrogates, such as post-mortem histology, cardiovascular imaging, and molecular characterisation in vivo and in vitro, rather than directly in pre-mortem human cardiac tissue. Using our heart bank of pre-mortem hearts procured according to the most stringent protocols, we examined ischemic (ICM) and dilated cardiomyopathy (DCM) -- the most common causes of HF and leading causes of cardiac transplantation1. We performed unbiased, comprehensive, paired proteomic and metabolomic analysis of 51 left ventricular (LV) samples from 44 cryopreserved pre-mortem human ICM and DCM hearts, including age-matched, healthy, histopathologically-normal donor controls of both genders for comparison. Data integration via pathway and correlation network analysis revealed overlapping and divergent disease pathways in ICM and DCM, and, strikingly, precise sex-specific differences within each disease that unveil the interaction of gender with HF. Identified core functional nodes in each disease may serve as novel therapeutic targets, and we provide all proteomic and metabolomic results via an interactive online repository (https://mengboli.shinyapps.io/heartomics/) as a publicly available resource.

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Molecular Remodeling of Ion Channels in Human Atrial and Ventricular Myocytes Associated with Ischemic Cardiomyopathy

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Transcription profiling of human hearts exhibiting ischemic and nonischemic cardiomyopathy

Project description: Not available

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2008-06-17 | E-GEOD-9128 | biostudies-arrayexpress

Proteomic analysis of donor and cardiomyopathy pre-mortem human hearts

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