Astrocye and oligodendrocyte – love at first sight with myelin consequences

ABSTRACT: One way by which astrocytes modulate oligodendrocytes’ activity is by delivering neurotransmitters and leukemia inhibitory factor (Lif) in the medium that bind oligodendrocyte receptors. Most of these receptors are involved in intercellular Ca2+-signaling (ICS). However, not much is known about the interactions between myelination (MYE) and ICS genes and how astrocyte nearness modulates the oligodendrocyte genomic myelination fabric. We profiled the transcriptomes of immortalized oligodendrocyte precursor cells (Oli-neu) when cultured alone or co-cultured with cortical astrocytes. The astrocytes were plated in cell culture insert systems that did not allow formation of gap junction channels with oligodendrocytes but permitted exchange of soluble factors via the culture medium. Remarkably,

ORGANISM(S): Mus musculus

SUBMITTER: Dumitru Iacobas 

PROVIDER: E-GEOD-18726 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress