Transcription profiling of mouse liver to identify the effect of intermittent hypoxia on gene expression in the liver of ob/ob mice

ABSTRACT: All animals were kept in a controlled environment (22-24 °C with a 12 h : 12 h light : dark cycle; lights on at 09.00) on a standard chow diet with free access to water. Five ob/ob mice (sample_ids GSM32865-GSM32869) were placed in the intermittent hypoxia (IH) chamber and subjected to IH for 12 consecutive weeks and compared to pair-fed control exposed to intermittent room (IA) air for 12 weeks in identical chambers (n = 5, sample_ids GSM32860-GSM32864). The IH and IA states were induced during the light phase alternating with 12 h of constant room air during the dark phase. The IH and IA groups were weight-matched daily during the experiment by varying food intake. Weight-matching was conducted in pairs. The signal intensity fluorescent images produced during samples hybridizations to Af

ORGANISM(S): Mus musculus

SUBMITTER: Dmitry Grigoryev 

PROVIDER: E-GEOD-1873 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress