Increased Expression of Angiogenic Genes in the Brains of Mouse Meg3-null Embryos

ABSTRACT: MEG3 (Maternally Expressed Gene 3) is a non-coding RNA that is highly expressed in the normal human brain and pituitary. Expression of MEG3 is lost in gonadotroph-derived clinically non-functioning pituitary adenomas. Meg3 knock-out mice were generated to identify targets and potential functions of this gene in embryonic development and tumorigenesis. Gene expression profiles were compared in the brains of Meg3-null embryos and wild-type litter-mate controls using microarray analysis. Microarray data were analyzed with GeneSifter which uses Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and Gene Ontology (GO) classifications to identify signaling cascades and functional categories of interest within the data set. Differences were found in signaling pathways and ontologies rel

ORGANISM(S): Mus musculus

SUBMITTER: Xun Zhang 

PROVIDER: E-GEOD-18742 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress