IMR90 bystander experiment 0.5 Gy alpha particle

ABSTRACT: The existence of a radiation bystander effect, in which non-irradiated cells respond to signals from irradiated cells, is well established. It raises concerns for the interpretation of risks from exposure to low doses of ionizing radiation. Sparse data exists about the bystander signaling mechanisms and the ability to transmit damaging effects both spatially and temporally. To understand early signaling and cellular changes in bystanders, we have measured global gene expression 30 minutes after direct and bystander exposure to alpha particle in primary human lung fibroblasts. Gene ontology and pathway analyses suggested that the earliest measured changes at 30 minutes after treatment are in cell structure, motility and adhesion categories and a significant number of genes belong to the cat

ORGANISM(S): Homo sapiens

SUBMITTER: Shanaz Ghandhi 

PROVIDER: E-GEOD-18760 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress