Transcription profiling of mouse 15P-1 Sertoli cell clones stably transfected with mouse Rhox5-expression vector reveals androgen-Induced Rhox homeobox genes modulate the expression of AR-regulated genes

ABSTRACT: Rhox5, the founding member of the reproductive homeobox on the X chromosome (Rhox) gene cluster, encodes a homeodomain-containing transcription factor that is selectively expressed in Sertoli cells, where it promotes the survival of male germ cells. To identify Rhox5-regulated genes, we generated 15P-1 Sertoli cell clones expressing physiological levels of Rhox5 from a stably transfected expression vector. Microarray analysis identified many genes altered in expression in response to Rhox5, including those encoding proteins controlling cell cycle regulation, apoptosis, metabolism, and cell-cell interactions. Fifteen of these Rhox5-regulated genes were chosen for further analysis. Analysis of Rhox5-null male mice indicated that at least 9 of these are Rhox5-regulated in the testes in vi

ORGANISM(S): Mus musculus

SUBMITTER: miles wilkinson 

PROVIDER: E-GEOD-18785 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress