Role of miR-210 in late stages of lung cancer: mitochondrial alterations associated with a modulation of HIF1 activity

ABSTRACT: Recent studies have identified miR-210 among a set of hypoxia-regulated miRNAs, and shown the central regulatory role played by HIF to control transcription of this miRNA. Contradictory data exist concerning the regulation and roles of miR-210 during cancer progression. miR-210 appears at the same time over-expressed in some solid tumors (breast, pancreas, head and neck carcinomas, gliomas) while often deleted in ovarian carcinoma. It has been shown that depending on the tissue type or cellular model, miR-210 was indeed able to either promote entry into the cell cycle and to inhibit apoptosis or rather repress tumor initiation. We show here deregulation of several miRNAs in human lung cancer biopsies, including an over-expression of miR-210 which appears specific of late-stages of the tum

ORGANISM(S): Homo sapiens

SUBMITTER: Kevin Lebrigand 

PROVIDER: E-GEOD-18805 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress