Expression data from human neutrophils exposed to uropathogenic and commensal Esherichia coli.

ABSTRACT: The establishment of bacterial infections at epithelial surfaces is determined by the balance of virulence attributes of the pathogen with the activity of innate host defenses. Polymorphonuclear leukocytes (PMN) are key responders in many bacterial infections, but the mechanisms by which pathogens subvert these early responses to establish infection are largely undefined. Here, we model these early interactions between human PMN and the primary cause of urinary tract infections, namely uropathogenic Escherichia coli (UPEC). Our objective was to define virulence phenotypes of uropathogens (as compared with laboratory and commensal E. coli strains) that permit evasion of PMN activity. We found that UPEC strains resist phagocytic killing and dampen the production of antimicrobial reactive

ORGANISM(S): Homo sapiens

SUBMITTER: Rekha Meyer 

PROVIDER: E-GEOD-18810 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress