Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: SMY Lee
PROVIDER: E-GEOD-18816 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20091214 12
Human disease caused by highly pathogenic avian influenza (HPAI) H5N1 can lead to a rapidly progressive viral pneumonia leading to acute respiratory distress syndrome. There is increasing evidence from clinical, animal models and in vitro data, which suggests a role for virus-induced cytokine dysregulation in contributing to the pathogenesis of human H5N1 disease. The key target cells for the virus in the lung are the alveolar epithelium and alveolar macrophages, and we have shown that, compared ...[more]