Transcription profiling of human placentas delivered by term spontaneous labour compared to those delivered by elective term Cesarean section

ABSTRACT: Differentially expressed mRNA transcripts in the placenta delivered by term spontaneous labour compared to those delivered by elective term cesarean section. We hypothesized that the labour process involves changes in mRNA expression in the placenta. To test this hypothesis, we interrogated the mRNA levels of >50,000 genes and transcript variants using gene expression microarray (Human Genome U133 Plus 2.0 Array, Affymetrix) on 5 placentas collected from term spontaneous delivery and another 5 placentas collected from elective term cesarean delivery. To minimize the effect of gestational age on gene expression, these two groups of placentas were matched for their gestational ages at delivery. We have identified 134 and 128 genes that were up- or down-regulated, respectively, for more than

ORGANISM(S): Homo sapiens

SUBMITTER: Stephen Chim 

PROVIDER: E-GEOD-18850 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress