Expression data from Fus/TLS-null KSL hematopoietic stem/progenitor cells

ABSTRACT: Fus is the gene for a member of the FET family of RNA-binding proteins often involved in chromosomal translocations to generate oncogenic fusion genes in human cancers. Fus participates in multiple cellular functions, including RNA processing and transport, transcriptional regulation, and genome integrity. We uncovered its critical role in the maintenance of hematopoietic stem cells (HSCs). Fus-/- fetal livers developed normally except for a mild reduction in numbers of colony-forming cells compared to the wild type. The proliferation and differentiation of Fus-/- hematopoietic progenitors were normal in vitro. However, the number of colony-forming cells present in long-term cocultures of Fus-/- hematopoietic progenitors and stromal cells was significantly reduced. Fus-/- HSCs had an impai

ORGANISM(S): Mus musculus

SUBMITTER: ATSUSHI IWAMA 

PROVIDER: E-GEOD-18853 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress