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Regulation of neuronal gene and miRNA expression by the complement protein C1q associated with neuroprotection

ABSTRACT: Identification of transcriptional profiles stimulated by the complement protein C1q in rat immature neurons associated with the C1q-dependent neuroprotection observed in vitro. Use of the unbiased whole genome microarray approach to identify genes regulated by C1q. Immature neurons grown in vitro for 3 days were stimulated with 10 nM C1q for 3h.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Marie Benoit

PROVIDER: E-GEOD-18860 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression.

Benoit Marie E ME Tenner Andrea J AJ

The Journal of neuroscience : the official journal of the Society for Neuroscience 20110301 9

Activation of the complement cascade, a powerful effector mechanism of the innate immune system, is associated with neuroinflammation but also with elimination of inappropriate synapses during development. Synthesis of C1q, a recognition component of the complement system, occurs in brain during ischemia/reperfusion and Alzheimer's disease, suggesting that C1q may be a response to injury. In vitro, C1q, in the absence of other complement proteins, improves neuronal viability and neurite outgrowt ...[more]

PMID: 21368058

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