Transcriptome Profiling of Human Embryos during Early Organogenesis

ABSTRACT: We here report transcriptome profiling of human embryos at six successive developmental stages (i.e., Carnegie Stages 9 to 14), representing the first comprehensive gene expression database of early human organogenesis. Through a series of data mining and comparisons with the transcriptome during mouse embryogenesis and the disparate genomic data in human embryonic stem cells, we revealed that development potential during early human organogenesis is orchestrated by two dominant categories of genes. Specifically, most gradually induced genes are largely differentiation related whereas those gradually repressed are involved in both stemness- and differentiation-relevant aspects of the developmental potential. Further through integrative mining we uncovered a molecular network that well cha

ORGANISM(S): Homo sapiens

SUBMITTER: Ying Jin 

PROVIDER: E-GEOD-18887 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress