Multi-component epigenetic control of pro-invasive genes in cancer cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andrei Chernov
PROVIDER: E-GEOD-18899 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Microarray-based transcriptional and epigenetic profiling of matrix metalloproteinases, collagens, and related genes in cancer.
Chernov Andrei V AV Baranovskaya Svetlana S Golubkov Vladislav S VS Wakeman Dustin R DR Snyder Evan Y EY Williams Roy R Strongin Alex Y AY
The Journal of biological chemistry 20100419 25
Epigenetic parameters (DNA methylation, histone modifications, and miRNAs) play a significant role in cancer. To identify the common epigenetic signatures of both the individual matrix metalloproteinases (MMPs) and the additional genes, the function of which is also linked to proteolysis, migration, and tumorigenesis, we performed epigenetic profiling of 486 selected genes in unrelated non-migratory MCF-7 breast carcinoma and highly migratory U251 glioma cells. Genome-wide transcriptional profil ...[more]
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