Gene expression profiling of pregnant and virgin mouse lung and liver

ABSTRACT: Metastasis depends on the ability of tumor cells to establish a relationship with the newly seeded host tissue that is conducive to their survival and proliferation. Recent evidence suggests that tumor cells regulate their own dissemination by preparing permissive “metastatic niches” within host tissues. However, the factors that are implicated in rendering tissues permissive for metastatic tumor growth have yet to be fully elucidated. Breast tumors arising during pregnancy display highly aggressive behaviour and early metastatic proclivity, raising the possibility that pregnancy may constitute a physiological condition of permissiveness for tumor dissemination. We show that during murine gestation, both the rate and degree of metastatic tumor growth are enhanced irrespective of tumor type

ORGANISM(S): Mus musculus

SUBMITTER: Paolo Provero 

PROVIDER: E-GEOD-18907 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress