Induction of target genes of AP2-Sp in AP2-O::Sp parasites

ABSTRACT: Sporozoite-specific genes were induced in parasites that express AP2-O whose AP2 domain was swapped with that of AP2-Sp. DNA construct encoding AP2 domain of AP2-Sp was introduced into P. bergei schizonts. It was integrated into the locus of the endogenious AP2-O gene, resulting in swap of the AP2-domain (AP2-O::Sp parasites). Gene expression was analyzed in ookinetes cultured for 20h.

ORGANISM(S): Plasmodium berghei

SUBMITTER: Masao Yuda 

PROVIDER: E-GEOD-18910 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress