RNA expression profiles in CD34+ and in stromal cells of patients with refractory anemia with ringed sideroblasts

ABSTRACT: Myelodysplastic syndromes (MDS) are a group of clonal hematological disorders characterized by ineffective hematopoiesis with morphological evidence of marrow cell dysplasia resulting in peripheral blood cytopenia. Microarray technology has permitted a refined high-throughput mapping of the transcriptional activity in the human genome. Noncoding-RNAs (ncRNAs) transcribed from intronic regions of genes are involved in a number of processes related to post-transcriptional control of gene expression, and in the regulation of exon-skipping and intron retention. Characterization of ncRNAs in progenitor cells and stromal cells of MDS patients could be strategic for understanding gene expression regulation in this disease. In this study, gene expression profiles of CD34+ and stromal cells of MDS

ORGANISM(S): Homo sapiens

SUBMITTER: Yuri Moreira 

PROVIDER: E-GEOD-18911 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress