RNA abundance in wild-type and rtt109 -/- Candida albicans, with and without peroxide stress

ABSTRACT: Candida albicans is a ubiquitous opportunistic pathogen that is the most prevalent cause of hospital-acquired fungal infections. In mammalian hosts, C. albicans is engulfed by phagocytes that attack the pathogen with DNA-damaging reactive oxygen species (ROS). Acetylation of histone H3 lysine 56 (H3K56) by the fungal-specific histone acetyltransferase Rtt109 is important for yeast model organisms to survive DNA damage and maintain genome integrity. To assess the importance of Rtt109 for C. albicans pathogenicity, we deleted the predicted homologue of Rtt109 in the clinical C. albicans isolate, SC5314. C. albicans rtt109 -/- mutant cells lack acetylated H3K56 (H3K56ac) and are hypersensitive to genotoxic agents. Additionally, rtt109 -/- mutant cells constitutively display increased H2A S129

ORGANISM(S): Candida albicans

SUBMITTER: Jessica Lopes da Rosa-Spiegler 

PROVIDER: E-GEOD-18936 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress