Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: William Muller
PROVIDER: E-GEOD-18996 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ursini-Siegel Josie J Cory Sean S Zuo Dongmei D Hardy William R WR Rexhepaj Elton E Lam Sonya S Schade Babette B Jirstrom Karin K Bjur Eva E Piccirillo Ciriaco A CA Denardo David D Coussens Lisa M LM Brennan Donal J DJ Gallagher William M WM Park Morag M Pawson Tony T Hallett Michael M Muller William J WJ
Cancer research 20101005 20
Using transgenic mouse models of breast cancer that ablate Src homology and collagen A (ShcA) expression or oncogene-coupled ShcA signaling, we previously showed that this adaptor is critical for mammary tumor onset and progression. We now provide the first evidence that ShcA regulates mammary tumorigenesis, in part, through its ability to regulate the adaptive immune response. Inactivation of ShcA signaling within tumor cells results in extensive CD4(+) T-cell infiltration and induction of a hu ...[more]