Expression data of Actinobacillus pleuropneumoniae 4074 and the M-NM-^TluxS mutant of Actinobacillus pleuropneumoniae 4074

ABSTRACT: LuxS is an enzyme involved in the activated methyl cycle and the by-product autoinducer 2 (AI-2) was a quorum sensing signal in some species. In our previous study, the functional LuxS in AI-2 production was verified in the porcine respiratory pathogen Actinobacillus pleuropneumoniae. Enhanced biofilm formation and reduced virulence were observed in the luxS mutant. To comprehensively understand the luxS function, in this study, the transcriptional profiles were compared between the A. pleuropneumoniae luxS mutant and its parental strain in four different growth phases using microarray. Many genes associated with infection were differentially expressed. The biofilm formation genes pgaABC in the luxS mutant were up-regulated in early exponential phase, while 8 genes associated with adhesion

ORGANISM(S): Actinobacillus pleuropneumoniae

SUBMITTER: Zhuofei Xu 

PROVIDER: E-GEOD-19056 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress