Transcription profiling of rat aortic smooth muscle cells after PDGF-BB treatment

ABSTRACT: Unlike other terminally differentiated cell types, vascular SMCs display remarkable phenotypic plasticity. The adult, differentiated state is traditionally defined by expression of well-characterized SMC contractile genes. Extracellular cues, however, can induce contractile SMCs to remodel toward a synthetic state characterized by a spectrum of proliferative, migratory, and inflammatory phenotypes. We used whole-genome expression arrays to to identify genes associated with SMC phenotypic modulation. Experiment Overall Design: Rat aortic SMCs were serum-starved for 72 hours and subsequently treated with either PDGF-BB or its respective vehicle (n=2). RNA samples were hybridzed to Affymetrix arrays with the intent to identify early genes associated with SMC phenotypic modulation.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Brian Wamhoff 

PROVIDER: E-GEOD-19106 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress