Profiling uterine fibroid specimens with an in-house array representing all 90 human tyrosine kinases and their ligands

ABSTRACT: The aim of this study is to compare the expression patterns of tyrosine kinases and their ligand activators between matched myometrium and leiomyoma tissues. For this, total RNA samples extracted from 42 pairs of matched fibroid and adjacent myometrial tissues were hybridized to a set of 840 customized oligonucleotide microarrays to compare the expression profiles of 244 selected human genes including all 90 tyrosine kinases and 103 ligands. Among the 244 genes surveyed, 38 were found to be differentially expressed between pairs of myometrium and fibroid tissues. Clustering analysis of the expression ratios of these 38 genes from 42 pairs of samples has led to the subdivision of fibroid samples into three groups, based on the expression ratios of two peptide ligands, CYR61 and EFNA4. Real-

ORGANISM(S): Homo sapiens

SUBMITTER: Xin Lu 

PROVIDER: E-GEOD-19127 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress