Gene expression data from children diagnosed with ALL in vitro sensitive or resistant to prednisolone

ABSTRACT: Although the prognosis for childhood Acute Lymphoblastic Leukemia (ALL) in general has improved tremendously over the last decades, the survival chances for infants (<1 year of age) with ALL remains poor. A major obstacle hampering successful treatment results in infant ALL is cellular resistance to several drugs currently used in the treatment of ALL, especially to prednisolone (or prednisone). Therefore we set out to search for genes differentially expressed between from infant (children <1 year of age) and non-infant (children >1 year of age) ALL samples either resistant or sensitive to prednisolone. The in vitro prednisolone response in primary infant and non-infant ALL samples was determined by 4-day cytotoxicity (MTT) assays. Patient samples were characterized as either sensitive or

ORGANISM(S): Homo sapiens

SUBMITTER: Ronald Stam 

PROVIDER: E-GEOD-19143 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress